LNX1

This gene encodes a membrane-bound protein that is involved in signal transduction and protein interactions. The encoded product is an E3 ubiquitin-protein ligase, which mediates ubiquitination and subsequent proteasomal degradation of proteins containing phosphotyrosine binding (PTB) domains. This protein may play an important role in tumorogenesis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene, which is located on chromosome 17, has been identified for this gene. [provided by RefSeq, Jul 2008]

Description

Ligand of numb-protein X 1

Tissue specificity

Low tissue specificity

Subcell location

Cell Junctions, Cytosol

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins

Chromosome

4 (53459301 - 53701405)

Ensembl ID

ENSG00000072201  (ver. 103.38)

Orthologs

Mouse Lnx1: ENSMUSG00000029228

UniProt

Q8TBB1

neXtProt

NX_Q8TBB1

Human splice variants
Mouse splice variants

Protein structure