UBAP1

This gene is a member of the UBA domain family, whose members include proteins having connections to ubiquitin and the ubiquitination pathway. The ubiquitin associated domain is thought to be a non-covalent ubiquitin binding domain consisting of a compact three helix bundle. This particular protein originates from a gene locus in a refined region on chromosome 9 undergoing loss of heterozygosity in nasopharyngeal carcinoma (NPC). Taking into account its cytogenetic location, this UBA domain family member is being studies as a putative target for mutation in nasopharyngeal carcinomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

Description

Ubiquitin associated protein 1

Tissue specificity

Low tissue specificity

Subcell location

Vesicles, Plasma membrane, Cytosol

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

9 (34179005 - 34252523)

Ensembl ID

ENSG00000165006  (ver. 103.38)

Orthologs

Mouse Ubap1: ENSMUSG00000028437

UniProt

Q9NZ09

neXtProt

NX_Q9NZ09

Human splice variants
Mouse splice variants

Protein structure