EOMES

This gene belongs to the TBR1 (T-box brain protein 1) sub-family of T-box genes that share the common DNA-binding T-box domain. The encoded protein is a transcription factor which is crucial for embryonic development of mesoderm and the central nervous system in vertebrates. The protein may also be necessary for the differentiation of effector CD8+ T cells which are involved in defense against viral infections. A similar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Description

Eomesodermin

Tissue specificity

Group enriched (brain, lymphoid tissue)

Subcell location

Nucleoplasm, Golgi apparatus, Cytosol

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transcription factors

Chromosome

3 (27715949 - 27722711)

Ensembl ID

ENSG00000163508  (ver. 103.38)

Orthologs

Mouse Eomes: ENSMUSG00000032446

UniProt

O95936

neXtProt

NX_O95936

Human splice variants
Mouse splice variants

Protein structure