Tissue expression
Cell line expression
Protein structure

F7

Coagulation factor VII
 
This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015]
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716 antibodies from 38 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
R&D Systems
14 antibodies
Novus Biologicals
53 antibodies
Proteintech Group
1 antibody
GeneTex
13 antibodies
antibodies-online
173 antibodies
Invitrogen Antibodies
30 antibodies
St John's Laboratory
2 antibodies
Biorbyt
57 antibodies
Cusabio Biotech Co., Ltd
7 antibodies
Aviva Systems Biology
9 antibodies
Boster Biological Technology
3 antibodies
OriGene
18 antibodies
Abnova Corporation
11 antibodies
Acris Antibodies GmbH
11 antibodies
Signalway Antibody LLC
1 antibody
NovoPro Bioscience Inc.
5 antibodies
Wuhan Fine Biotech Co., Ltd.
1 antibody
Abbkine Scientific Co.Ltd.
1 antibody
Green Mountain Antibodies
1 antibody
MyBioSource
22 antibodies
RayBiotech, Inc.
3 antibodies
NSJ Bioreagents
2 antibodies
ProSci
3 antibodies
RabMAbs
2 antibodies
Abbexa
10 antibodies
Creative Biolabs
49 antibodies
Creative Diagnostics
15 antibodies
Leading Biology
5 antibodies
Molecular Innovations
9 antibodies
Absolute Antibody
5 antibodies
MilliporeSigma / Merck KGaA
3 antibodies
United States Biological
3 antibodies
GenWay
1 antibody
Abgent
4 antibodies
Sino Biological Inc.
3 antibodies
Exalpha Biologicals, Inc.
1 antibody