BUB1B

This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008]

Description

BUB1 mitotic checkpoint serine/threonine kinase B

Protein family

Cancer-related genes, Disease related genes, Enzymes, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Potential drug targets, Predicted intracellular proteins, Protein evidence (Peptideatlas)

Chromosome

15:q15.1 (40161023 - 40221136)

Ensembl ID

ENSG00000156970  (ver. 98.38)

Orthologs

-

UniProt

O60566

neXtProt

NX_O60566

Human splice variants