CLEC4M

gene product
CD209L, CD299, DC-SIGN2, DC-SIGNR, DCSIGNR, HP10347, LSIGN
This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants. [provided by RefSeq, Feb 2009]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Validated within AVI
Eligible for validation within AVI
426 antibodies from 28 providers.

Antibody properties

General

Applications

or Cancel
Antibody
Novus Biologicals
76 antibodies
Invitrogen Antibodies
6 antibodies
R&D Systems
9 antibodies
NovoPro Bioscience Inc.
2 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
LifeSpan BioSciences, Inc.
54 antibodies
antibodies-online
148 antibodies
OriGene
10 antibodies
Biorbyt
20 antibodies
Aviva Systems Biology
4 antibodies
Atlas Antibodies
1 antibody
Proteintech Group
1 antibody
GeneTex
4 antibodies
ProSci
2 antibodies
St John's Laboratory
2 antibodies
Boster Biological Technology
1 antibody
Abnova Corporation
6 antibodies
Creative Biolabs
25 antibodies
Miltenyi Biotec
12 antibodies
Creative Diagnostics
5 antibodies
Absolute Antibody
2 antibodies
MyBioSource
1 antibody
RabMAbs
1 antibody
Sigma-Aldrich
4 antibodies
Abgent
2 antibodies
GenWay
1 antibody
United States Biological
1 antibody