ABCC9

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extra-pancreatic ATP-sensitive potassium channels. Mutations in this gene are associated with cardiomyopathy dilated type 1O. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2011]

Description

ATP binding cassette subfamily C member 9

Tissue specificity

Tissue enhanced (liver)

Subcell location

Nucleoplasm, Cytosol

Predicted location

Membrane

Protein family

Disease related genes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters

Chromosome

12 (21797389 - 21942529)

Ensembl ID

ENSG00000069431  (ver. 103.38)

Orthologs

Mouse Abcc9: ENSMUSG00000030249

UniProt

O60706

neXtProt

NX_O60706

Human splice variants
Mouse splice variants

Protein structure