Tissue expression
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Protein structure

PDP1

Pyruvate dehyrogenase phosphatase catalytic subunit 1
PDH, PDP, PPM2A, PPM2C 
Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2009]
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286 antibodies from 32 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Proteintech Group
1 antibody
Invitrogen Antibodies
9 antibodies
antibodies-online
84 antibodies
Biorbyt
17 antibodies
Atlas Antibodies
3 antibodies
Novus Biologicals
4 antibodies
Cusabio Biotech Co., Ltd
6 antibodies
St John's Laboratory
3 antibodies
Boster Biological Technology
2 antibodies
NovoPro Bioscience Inc.
1 antibody
Abnova Corporation
3 antibodies
OriGene
2 antibodies
Abgent
1 antibody
Acris Antibodies GmbH
1 antibody
Aviva Systems Biology
1 antibody
R&D Systems
1 antibody
Bioworld Technology, Inc
2 antibodies
GeneTex
2 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Affinity Biosciences
1 antibody
Cell Signaling Technology, Inc
1 antibody
ProSci
1 antibody
Wuhan Fine Biotech Co., Ltd.
1 antibody
Abbexa
9 antibodies
Creative Biolabs
6 antibodies
MyBioSource
2 antibodies
United States Biological
61 antibodies
MilliporeSigma / Merck KGaA
6 antibodies
EMD Millipore
1 antibody
Creative Diagnostics
1 antibody