Tissue expression
Cell line expression

NPC1L1

gene product
SLC65A2 
The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
More gene data

Antibodies

 

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Supportive data in Antibodypedia
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206 antibodies from 22 providers.

Antibody properties

Applications

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AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
46 antibodies
antibodies-online
57 antibodies
GeneTex
3 antibodies
LifeSpan BioSciences, Inc.
49 antibodies
Invitrogen Antibodies
5 antibodies
OriGene
2 antibodies
Affinity Biosciences
1 antibody
Cell Signaling Technology, Inc
1 antibody
Cusabio Biotech Co., Ltd
1 antibody
Proteintech Group
1 antibody
RabMAbs
2 antibodies
Biorbyt
10 antibodies
Aviva Systems Biology
2 antibodies
St John's Laboratory
3 antibodies
Abnova Corporation
1 antibody
United States Biological
14 antibodies
Abbexa
2 antibodies
MyBioSource
2 antibodies
Creative Diagnostics
1 antibody
ProSci
1 antibody
Creative Biolabs
1 antibody
MilliporeSigma / Merck KGaA
1 antibody