Tissue expression
Cell line expression
Protein structure
OGDH
Oxoglutarate dehydrogenaseE1k, KGD1, OGDC-E1, OGDH2
This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2009]
Top validated antibodies |
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| Proteintech Group | 58 references | Polyclonal |
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| Invitrogen Antibodies | 3 references | Polyclonal |
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| GeneTex | 2 references | Polyclonal |
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| LSBio | Polyclonal |
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| Atlas Antibodies | 5 references | Polyclonal |
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