MAPK10

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]

Description

Mitogen-activated protein kinase 10

Tissue specificity

Tissue enhanced (brain)

Predicted location

Intracellular

Protein family

Disease related genes
Enzymes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Potential drug targets
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
RAS pathway related proteins

Chromosome

4 (85990007 - 86594625)

Ensembl ID

ENSG00000109339  (ver. 103.38)

Orthologs

Mouse Mapk10: ENSMUSG00000046709

UniProt

P53779

neXtProt

NX_P53779

Human splice variants
Mouse splice variants

Protein structure