FBLIM1

This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Description

Filamin binding LIM protein 1

Tissue specificity

Low tissue specificity

Subcell location

Nucleoli fibrillar center, Cell Junctions, Focal adhesion sites

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (15756607 - 15786594)

Ensembl ID

ENSG00000162458  (ver. 103.38)

Orthologs

Mouse Fblim1: ENSMUSG00000006219

UniProt

Q8WUP2

neXtProt

NX_Q8WUP2

Human splice variants
Mouse splice variants

Protein structure