MUC2

This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Downregulation of this gene has been observed in patients with Crohn disease and ulcerative colitis. [provided by RefSeq, Oct 2016]

Description

Mucin 2, oligomeric mucus/gel-forming

Tissue specificity

Tissue enriched (intestine)

Predicted location

Intracellular

Protein family

Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

11:p15.5 (1074875 - 1110511)

Ensembl ID

ENSG00000198788  (ver. 103.38)

Orthologs

-

UniProt

 

neXtProt

 

Human splice variants