NEK4

The protein encoded by this gene is a serine/threonine protein kinase required for normal entry into replicative senescence. The encoded protein also is involved in cell cycle arrest in response to double-stranded DNA damage. Finally, this protein plays a role in maintaining cilium integrity, and defects in this gene have been associated with ciliopathies. [provided by RefSeq, Jan 2017]

Description

NIMA related kinase 4

Protein family

Enzymes, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted intracellular proteins, Protein evidence (Peptideatlas)

Chromosome

3:p21.1 (52708444 - 52770946)

Ensembl ID

ENSG00000114904  (ver. 99.38)

Orthologs

Mouse Nek4: ENSMUSG00000021918

UniProt

P51957

neXtProt

NX_P51957

Human splice variants
Mouse splice variants