Tissue expression
Cell line expression
Protein structure
ABCG8
ATP binding cassette subfamily G member 8GBD4
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions to exclude non-cholesterol sterol entry at the intestinal level, promote excretion of cholesterol and sterols into bile, and to facilitate transport of sterols back into the intestinal lumen. It is expressed in a tissue-specific manner in the liver, intestine, and gallbladder. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG5. Mutations in this gene may contribute to sterol accumulation and atherosclerosis, and have been observed in patients with sitosterolemia. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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Novus Biologicals | NBP1-71706 | 8 references | Monoclonal |
WB
ICC
IP
IHC |
|
Boster Biological Technology | A01482-2 | 1 references | Polyclonal |
WB
EL
ICC
FC |
|
antibodies-online | ABIN438175 | 10 references | Polyclonal |
WB
ICC |
|
Cusabio Biotech Co., Ltd | CSB-PA875651LA01HU | Polyclonal |
WB
EL
ICC
IHC |
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Affinity Biosciences | DF6673 | Polyclonal |
WB
EL
ICC
IHC |
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