ITGA7

The protein encoded by this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. They mediate a wide spectrum of cell-cell and cell-matrix interactions, and thus play a role in cell migration, morphologic development, differentiation, and metastasis. This protein functions as a receptor for the basement membrane protein laminin-1. It is mainly expressed in skeletal and cardiac muscles and may be involved in differentiation and migration processes during myogenesis. Defects in this gene are associated with congenital myopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2009]

Description

Integrin subunit alpha 7

Tissue specificity

Tissue enhanced (skeletal muscle)

Subcell location

Nuclear speckles, Vesicles, Plasma membrane

Predicted location

Intracellular, Membrane

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

12 (55684568 - 55716043)

Ensembl ID

ENSG00000135424  (ver. 103.38)

Orthologs

Mouse Itga7: ENSMUSG00000025348

UniProt

Q13683

neXtProt

NX_Q13683

Human splice variants
Mouse splice variants

Protein structure