ESX1

This gene encodes a dual-function 65 kDa protein that undergoes proteolytic cleavage to produce a 45 kDa N-terminal fragment with a paired-like homeodomain and a 20 kDa C-terminal fragment with a proline-rich domain. The C-terminal fragment localizes to the cytoplasm while the N-terminal fragment localizes exclusively to the nucleus. In contrast to human, the mouse homolog has a novel PN/PF motif in the C-terminus and is paternally imprinted in placental tissue. This gene likely plays a role in placental development and spermatogenesis. [provided by RefSeq, Jan 2010]

Description

ESX homeobox 1

Protein family

Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Transcription factors

Chromosome

X:q22.2 (104250038 - 104254933)

Ensembl ID

ENSG00000123576  (ver. 99.38)

Orthologs

Mouse Esx1: ENSMUSG00000023443

UniProt

Q8N693

neXtProt

NX_Q8N693

Human splice variants
Mouse splice variants