Tissue expression
Cell line expression
Protein structure
DMTF1
Cyclin D binding myb like transcription factor 1DMP1, DMTF, hDMP1, MRUL
This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Top validated antibodies |
|||||
Novus Biologicals | H00009988-M03 | Monoclonal |
WB
EL
ICC
IHC |
||
Invitrogen Antibodies | PA5-29466 | 2 references | Polyclonal |
WB
OA |
|
Abnova Corporation | H00009988-M03 | Monoclonal |
WB
ICC
IHC
|
||
LSBio | LS-C133617 | Monoclonal |
WB
EL
ICC
IHC |
||
antibodies-online | ABIN396562 | Monoclonal |
WB
ICC
IHC
|
All Antibodies
Filters
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider