IRS4

IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.. [provided by RefSeq, Jul 2008]

Description

insulin receptor substrate 4

Protein family

Cancer-related genes, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Protein evidence (Peptideatlas)

Chromosome

X:q22.3 (108732482 - 108736409)

Ensembl ID

ENSG00000133124  (ver. 99.38)

Orthologs

Mouse Irs4: ENSMUSG00000054667

UniProt

O14654

neXtProt

NX_O14654

Human splice variants
Mouse splice variants