Tissue expression
Cell line expression
Protein structure
PTPRN2
Protein tyrosine phosphatase receptor type N2IA-2beta, ICAAR, KIAA0387, phogrin
This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Top validated antibodies |
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Atlas Antibodies | ![]() |
2 references | Polyclonal |
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LSBio | ![]() |
Polyclonal |
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Biorbyt | ![]() |
Polyclonal |
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Invitrogen Antibodies | ![]() |
Polyclonal |
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antibodies-online | ![]() |
Polyclonal |
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