ASIC2

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Feb 2012]

Description

Acid sensing ion channel subunit 2

Tissue specificity

Group enriched (brain, cervix, endometrium , retina)

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

17 (33013087 - 34174964)

Ensembl ID

ENSG00000108684  (ver. 103.38)

Orthologs

Mouse Asic2: ENSMUSG00000020704

UniProt

Q16515

neXtProt

NX_Q16515

Human splice variants
Mouse splice variants