CCL11

This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014]

Description

C-C motif chemokine ligand 11

Protein family

Cancer-related genes, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Predicted secreted proteins

Chromosome

17:q12 (34285742 - 34288334)

Ensembl ID

ENSG00000172156  (ver. 98.38)

Orthologs

Mouse Ccl11: ENSMUSG00000020676

UniProt

P51671

neXtProt

NX_P51671

Human splice variants
Mouse splice variants