Tissue expression
Cell line expression
Protein structure
RNF8
Ring finger protein 8KIAA0646
The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Top validated antibodies |
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| Proteintech Group | 20 references | Polyclonal |
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| Invitrogen Antibodies | Polyclonal |
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| LSBio | Polyclonal |
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| NovoPro Bioscience Inc. | Polyclonal |
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| antibodies-online | 6 references | Polyclonal |
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