MEN1

This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]

Description

menin 1

Protein family

Cancer-related genes, Disease related genes, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Protein evidence (Peptideatlas)

Chromosome

11:q13.1 (64803510 - 64811294)

Ensembl ID

ENSG00000133895  (ver. 99.38)

Orthologs

Mouse Men1: ENSMUSG00000024947

UniProt

O00255

neXtProt

NX_O00255

Human splice variants
Mouse splice variants