C5

gene product
C5a, C5b, CPAMD4
This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mutations in this gene cause complement component 5 deficiency, a disease characterized by recurrent bacterial infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Validated within AVI
Eligible for validation within AVI
719 antibodies from 37 providers.

Antibody properties

General

Applications

or Cancel
AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
59 antibodies
antibodies-online
175 antibodies
Biorbyt
41 antibodies
Aviva Systems Biology
4 antibodies
R&D Systems
9 antibodies
NSJ Bioreagents
4 antibodies
NovoPro Bioscience Inc.
2 antibodies
Abgent
3 antibodies
GeneTex
14 antibodies
LifeSpan BioSciences, Inc.
82 antibodies
St John's Laboratory
2 antibodies
Invitrogen Antibodies
13 antibodies
OriGene
15 antibodies
Creative Biolabs
145 antibodies
Abbiotec
3 antibodies
ProSci
1 antibody
Signalway Antibody LLC
1 antibody
BioLegend
8 antibodies
Acris Antibodies GmbH
18 antibodies
RabMAbs
2 antibodies
Abbexa
4 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Affinity Biosciences
1 antibody
Antibodies.com
1 antibody
Creative Diagnostics
21 antibodies
MyBioSource
9 antibodies
Arigo
1 antibody
Atlas Antibodies
1 antibody
United States Biological
14 antibodies
Absolute Antibody
24 antibodies
Sino Biological Inc.
5 antibodies
GenWay
3 antibodies
Enzo Life Sciences
5 antibodies
Sigma-Aldrich
1 antibody
RayBiotech, Inc.
1 antibody
Abnova Corporation
2 antibodies