MGLL

This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and nociperception through hydrolysis of the endocannabinoid 2-arachidonoylglycerol. Expression of this gene may play a role in cancer tumorigenesis and metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

Description

monoglyceride lipase

Protein family

Enzymes, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Predicted secreted proteins, Protein evidence (Ezkurdia et al 2014), Protein evidence (Kim et al 2014)

Chromosome

3:q21.3 (127689062 - 127823250)

Ensembl ID

ENSG00000074416  (ver. 84.38)

Orthologs

Mouse Mgll: ENSMUSG00000033174

UniProt

Q99685

neXtProt

NX_Q99685

Human splice variants
Mouse splice variants