GRK2

This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease. [provided by RefSeq, Sep 2017]

Description

G protein-coupled receptor kinase 2

Protein family

Enzymes, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted intracellular proteins, Protein evidence (Peptideatlas)

Chromosome

11:q13.2 (67266473 - 67286556)

Ensembl ID

ENSG00000173020  (ver. 99.38)

Orthologs

Mouse Grk2: ENSMUSG00000024858

UniProt

P25098

neXtProt

NX_P25098

Human splice variants
Mouse splice variants