PSMC2

gene product
MSS1, Nbla10058, S7
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2011]
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356 antibodies from 32 providers.

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Antibody
Proteintech Group
1 antibody
NovoPro Bioscience Inc.
4 antibodies
antibodies-online
112 antibodies
Biorbyt
14 antibodies
Invitrogen Antibodies
2 antibodies
Novus Biologicals
24 antibodies
OriGene
4 antibodies
Atlas Antibodies
2 antibodies
GeneTex
3 antibodies
Abnova Corporation
3 antibodies
LifeSpan BioSciences, Inc.
55 antibodies
Enzo Life Sciences
9 antibodies
Bioworld Technology, Inc
1 antibody
Abgent
2 antibodies
St John's Laboratory
2 antibodies
Affinity Biosciences
1 antibody
Bethyl Laboratories
1 antibody
Creative Diagnostics
4 antibodies
Acris Antibodies GmbH
1 antibody
Aviva Systems Biology
3 antibodies
MyBioSource
5 antibodies
NSJ Bioreagents
1 antibody
United States Biological
44 antibodies
Abbexa
9 antibodies
Creative Biolabs
7 antibodies
Boster Biological Technology
1 antibody
Cell Signaling Technology, Inc
1 antibody
Sigma-Aldrich
6 antibodies
Leading Biology
2 antibodies
EMD Millipore
1 antibody
GenWay
1 antibody