SOX30

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein acts as a transcriptional regulator when present in a complex with other proteins. It can activate p53 transcription to promote tumor cell apoptosis in lung cancer. The protein may be involved in the differentiation of developing male germ cells. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Apr 2015]

Description

SRY-box transcription factor 30

Tissue specificity

Tissue enriched (testis)

Subcell location

Nucleoplasm, Vesicles, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Transcription factors

Chromosome

5:q33.3 (157625679 - 157671480)

Ensembl ID

ENSG00000039600  (ver. 103.38)

Orthologs

Mouse Sox30: ENSMUSG00000040489

UniProt

O94993

neXtProt

NX_O94993

Human splice variants
Mouse splice variants