FZD4

This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence. [provided by RefSeq, Jul 2008]

Description

Frizzled class receptor 4

Tissue specificity

Tissue enhanced (adipose tissue)

Subcell location

Nucleoplasm, Plasma membrane

Predicted location

Membrane

Protein family

CD markers
Disease related genes
G-protein coupled receptors
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Potential drug targets
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

11 (86945679 - 86955395)

Ensembl ID

ENSG00000174804  (ver. 103.38)

Orthologs

Mouse Fzd4: ENSMUSG00000049791

UniProt

Q9ULV1

neXtProt

NX_Q9ULV1

Human splice variants
Mouse splice variants

Protein structure