Tissue expression
Cell line expression
Protein structure

PAWR

Pro-apoptotic WT1 regulator
par-4, PAR4 
This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases. [provided by RefSeq, Aug 2017]
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442 antibodies from 40 providers.

Antibody properties

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AntibodyRefsTypeWBELICCIPIHCFC
NSJ Bioreagents
1 antibody
antibodies-online
117 antibodies
Biorbyt
62 antibodies
Boster Biological Technology
3 antibodies
Invitrogen Antibodies
19 antibodies
Proteintech Group
1 antibody
Affinity Biosciences
4 antibodies
Acris Antibodies GmbH
13 antibodies
Abnova Corporation
8 antibodies
Cell Signaling Technology, Inc
2 antibodies
Atlas Antibodies
1 antibody
Novus Biologicals
6 antibodies
OriGene
13 antibodies
St John's Laboratory
4 antibodies
Cusabio Biotech Co., Ltd
5 antibodies
Aviva Systems Biology
3 antibodies
FineTest Biotech
1 antibody
NovoPro Bioscience Inc.
1 antibody
GeneTex
10 antibodies
Bioworld Technology, Inc
2 antibodies
Abgent
4 antibodies
Bethyl Laboratories
2 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Arigo
3 antibodies
RabMAbs
4 antibodies
ProSci
1 antibody
R&D Systems
1 antibody
Abbexa
9 antibodies
Spring Bioscience
4 antibodies
MyBioSource
6 antibodies
Creative Diagnostics
3 antibodies
Creative Biolabs
10 antibodies
RayBiotech, Inc.
2 antibodies
United States Biological
51 antibodies
Leading Biology
3 antibodies
MilliporeSigma / Merck KGaA
5 antibodies
Abbiotec
1 antibody
EMD Millipore
1 antibody