PAWR

This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases. [provided by RefSeq, Aug 2017]

Description

Pro-apoptotic WT1 regulator

Tissue specificity

Low tissue specificity

Subcell location

Plasma membrane, Actin filaments

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

12 (79574979 - 79690964)

Ensembl ID

ENSG00000177425  (ver. 103.38)

Orthologs

Mouse Pawr: ENSMUSG00000035873

UniProt

Q96IZ0

neXtProt

NX_Q96IZ0

Human splice variants
Mouse splice variants

Protein structure