ASIC3

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]

Description

Acid sensing ion channel subunit 3

Tissue specificity

Tissue enhanced (testis)

Subcell location

Nucleoplasm, Cytosol

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins

Chromosome

7 (151048292 - 151052756)

Ensembl ID

ENSG00000213199  (ver. 103.38)

Orthologs

Mouse Asic3: ENSMUSG00000038276

UniProt

Q9UHC3

neXtProt

NX_Q9UHC3

Human splice variants
Mouse splice variants

Protein structure