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Protein structure
MUTYH
MutY DNA glycosylaseMYH
This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. This gene product is thought to play a role in signaling apoptosis by the introduction of single-strand breaks following oxidative damage. Mutations in this gene result in heritable predisposition to colorectal cancer, termed MUTYH-associated polyposis (MAP). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017]
Top validated antibodies |
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| Novus Biologicals |  H00004595-M01 |
10 references | Monoclonal |
WB
EL
ICC
IP
IHC
BN
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| Proteintech Group | 19650-1-AP |
3 references | Polyclonal |
WB
EL
IP
IHC
|
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| LSBio | LS-C354036 |
Polyclonal |
WB
ICC
IHC
|
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| antibodies-online | ABIN561883 |
7 references | Monoclonal |
WB
EL
IP
|
|
| Abnova Corporation | H00004595-M01 |
7 references | Monoclonal |
WB
EL
IP
|
|
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