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Protein structure
POLH
DNA polymerase etaRAD30A, XP-V
This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
Top validated antibodies |
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| LSBio |  LS-C832109 |
Polyclonal |
WB
EL
IHC
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| GeneTex | GTX54545 |
1 references | Polyclonal |
WB
ICC
IHC
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| Novus Biologicals | NB100-60424 |
2 references | Polyclonal |
WB
IP
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| Cusabio Biotech Co., Ltd | CSB-PA018321LA01HU |
Polyclonal |
WB
EL
ICC
IHC
|
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| Biorbyt | orb2618971 |
Polyclonal |
WB
ICC
IHC
FC
|
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