GRK5

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008]

Description

G protein-coupled receptor kinase 5

Tissue specificity

Low tissue specificity

Subcell location

Nuclear membrane, Nuclear speckles, Plasma membrane

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

10 (119207571 - 119459745)

Ensembl ID

ENSG00000198873  (ver. 103.38)

Orthologs

Mouse Grk5: ENSMUSG00000003228

UniProt

P34947

neXtProt

NX_P34947

Human splice variants
Mouse splice variants

Protein structure