ICA1

This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

Description

islet cell autoantigen 1

Protein family

Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Predicted membrane proteins, Protein evidence (Ezkurdia et al 2014), Protein evidence (Kim et al 2014)

Chromosome

7:p21.3 (8113184 - 8262687)

Ensembl ID

ENSG00000003147  (ver. 84.38)

Orthologs

Mouse Ica1: ENSMUSG00000062995

UniProt

Q05084

neXtProt

NX_Q05084

Human splice variants
Mouse splice variants