SRP68

This gene encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RNA and six protein subunits. The encoded protein is the 68kDa component of the SRP, and forms a heterodimer with the 72kDa subunit that is required for SRP function. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and three pseudogenes of this gene are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, May 2012]

Description

Signal recognition particle 68

Tissue specificity

Tissue enhanced (brain)

Subcell location

Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

17:q25.1 (76038775 - 76072517)

Ensembl ID

ENSG00000167881  (ver. 103.38)

Orthologs

Mouse Srp68: ENSMUSG00000020780

UniProt

Q9UHB9

neXtProt

NX_Q9UHB9

Human splice variants
Mouse splice variants