Tissue expression
Cell line expression
Protein structure
PSMD4
Proteasome 26S subunit, non-ATPase 4AF, AF-1, Rpn10, S5A
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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Proteintech Group | 14899-1-AP | 14 references | Polyclonal |
WB
EL
ICC
IHC
FC
|
|
Invitrogen Antibodies | PA5-118210 | Polyclonal |
WB
ICC
IP
IHC
OA
|
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NSJ Bioreagents | RQ8154 | Polyclonal |
WB
EL
ICC
IHC
FC
|
||
Atlas Antibodies | HPA038807 | Polyclonal |
WB
ICC
IHC
|
||
NovoPro Bioscience Inc. | 114400 | Polyclonal |
WB
EL
ICC
IHC
FC
|
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