PTPN12

gene product
PTP-PEST, PTPG1
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
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132 antibodies from 29 providers.

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Novus Biologicals
7 antibodies
Atlas Antibodies
1 antibody
Invitrogen Antibodies
3 antibodies
Bethyl Laboratories
6 antibodies
antibodies-online
35 antibodies
GeneTex
2 antibodies
LifeSpan BioSciences, Inc.
31 antibodies
Cell Signaling Technology, Inc
2 antibodies
Biorbyt
6 antibodies
Acris Antibodies GmbH
2 antibodies
Abnova Corporation
6 antibodies
OriGene
4 antibodies
NovoPro Bioscience Inc.
4 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
NSJ Bioreagents
2 antibodies
Aviva Systems Biology
1 antibody
Creative Diagnostics
2 antibodies
MyBioSource
2 antibodies
Abiocode, Inc.
1 antibody
Boster Biological Technology
1 antibody
RayBiotech, Inc.
1 antibody
ProSci
3 antibodies
Sigma-Aldrich
3 antibodies
EMD Millipore
1 antibody
Exalpha Biologicals, Inc.
1 antibody
St John's Laboratory
1 antibody
Abgent
1 antibody
Creative Biolabs
1 antibody
United States Biological
1 antibody