PTPN7

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2010]

Description

Protein tyrosine phosphatase non-receptor type 7

Tissue specificity

Group enriched (bone marrow, lymphoid tissue)

Subcell location

Microtubules, Mitotic spindle, Cytosol

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (202147013 - 202161588)

Ensembl ID

ENSG00000143851  (ver. 103.38)

Orthologs

Mouse Ptpn7: ENSMUSG00000031506

UniProt

P35236

neXtProt

NX_P35236

Human splice variants
Mouse splice variants

Protein structure