ACVR1C

ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]). [supplied by OMIM, Mar 2008]

Description

activin A receptor type 1C

Protein family

Enzymes, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Predicted membrane proteins

Chromosome

2:q24.1 (157526767 - 157628864)

Ensembl ID

ENSG00000123612  (ver. 99.38)

Orthologs

Mouse Acvr1c: ENSMUSG00000026834

UniProt

Q8NER5

neXtProt

NX_Q8NER5

Human splice variants
Mouse splice variants