ALK

gene product
CD246
This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X). [provided by RefSeq, Jan 2011]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Validated within AVI
Eligible for validation within AVI
1102 antibodies from 38 providers.

Antibody properties

General

Applications

or Cancel
Antibody
OriGene
565 antibodies
Cell Signaling Technology, Inc
22 antibodies
GeneTex
7 antibodies
Novus Biologicals
61 antibodies
Invitrogen Antibodies
12 antibodies
Abnova Corporation
20 antibodies
Aviva Systems Biology
10 antibodies
Biorbyt
65 antibodies
Affinity Biosciences
9 antibodies
NovoPro Bioscience Inc.
11 antibodies
antibodies-online
3 antibodies
Proteintech Group
2 antibodies
NSJ Bioreagents
8 antibodies
Arigo
5 antibodies
Acris Antibodies GmbH
28 antibodies
R&D Systems
3 antibodies
Abgent
4 antibodies
Atlas Antibodies
1 antibody
Boster Biological Technology
2 antibodies
St John's Laboratory
10 antibodies
Antibodies.com
1 antibody
Everest Biotech
2 antibodies
RabMAbs
4 antibodies
Creative Biolabs
61 antibodies
Abbkine Scientific Co.Ltd.
7 antibodies
ProSci
6 antibodies
MyBioSource
12 antibodies
Bioworld Technology, Inc
1 antibody
Spring Bioscience
12 antibodies
Miltenyi Biotec
8 antibodies
Creative Diagnostics
14 antibodies
GenWay
2 antibodies
United States Biological
67 antibodies
RayBiotech, Inc.
2 antibodies
Sigma-Aldrich
3 antibodies
LifeSpan BioSciences, Inc.
1 antibody
Abbexa
3 antibodies