ALDH1A2

This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2011]

Description

Aldehyde dehydrogenase 1 family member A2

Tissue specificity

Tissue enhanced (endometrium , fallopian tube)

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

15 (57953424 - 58497866)

Ensembl ID

ENSG00000128918  (ver. 103.38)

Orthologs

Mouse Aldh1a2: ENSMUSG00000013584

UniProt

O94788

neXtProt

NX_O94788

Human splice variants
Mouse splice variants

Protein structure