NFKBIZ

This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

NFKB inhibitor zeta

Tissue specificity

Tissue enriched (bone marrow)

Subcell location

Nuclear speckles, Cytoplasmic bodies

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transcription factors

Chromosome

3 (101827991 - 101861022)

Ensembl ID

ENSG00000144802  (ver. 103.38)

Orthologs

Mouse Nfkbiz: ENSMUSG00000035356

UniProt

Q9BYH8

neXtProt

NX_Q9BYH8

Human splice variants
Mouse splice variants

Protein structure