RNF4

The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Jul 2010]

Description

Ring finger protein 4

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nuclear bodies, Microtubule ends

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

4:p16.3 (2462220 - 2625320)

Ensembl ID

ENSG00000063978  (ver. 103.38)

Orthologs

Mouse Rnf4: ENSMUSG00000029110

UniProt

P78317

neXtProt

NX_P78317

Human splice variants
Mouse splice variants