Tissue expression
Cell line expression
Protein structure
PRDM9
PR/SET domain 9KMT8B, MSBP3, PFM6, ZNF899
The protein encoded by this gene is a zinc finger protein with histone methyltransferase activity that catalyzes histone H3 lysine 4 trimethylation (H3K4me3) during meiotic prophase. This protein contains multiple domains, including a Kruppel-associated box (KRAB) domain, an SSX repression domain (SSXRD), a PRD1-BF1 and RIZ homologous region, a subclass of SET (PR/SET) domain, and a tandem array of C2H2 zinc fingers. The zinc finger array recognizes a short sequence motif, leading to local H3K4me3, and meiotic recombination hotspot activity. The observed allelic variation alters the DNA-binding sequence specificity of the protein, resulting in distinct meiotic recombination hotspots amongst individuals and populations. Multiple alternate alleles of this gene have been described. [provided by RefSeq, Jul 2015]
Top validated antibodies |
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Invitrogen Antibodies | PA5-41161 | 1 references | Polyclonal |
WB
IHC
OA
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antibodies-online | ABIN405037 | 1 references | Polyclonal |
WB
IHC |
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OriGene | AP55012SU-N | Polyclonal |
WB
EL
IHC
|
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Biorbyt | orb1089927 | Monoclonal |
EL
ICC
ChIP
|
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Aviva Systems Biology | ARP35967_P050 | Polyclonal |
WB
IHC |
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Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider