DROSHA

Members of the ribonuclease III superfamily of double-stranded (ds) RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells (Fortin et al., 2002 [PubMed 12191433]). The RNase III Drosha is the core nuclease that executes the initiation step of microRNA (miRNA) processing in the nucleus (Lee et al., 2003 [PubMed 14508493]). [supplied by OMIM, Mar 2008]

Description

drosha, ribonuclease type III

Protein family

Enzymes, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Protein evidence (Ezkurdia et al 2014), Protein evidence (Kim et al 2014)

Chromosome

5:p13.3 (31400497 - 31532196)

Ensembl ID

ENSG00000113360  (ver. 84.38)

Orthologs

Mouse Drosha: ENSMUSG00000022191

UniProt

Q9NRR4

neXtProt

NX_Q9NRR4

Human splice variants
Mouse splice variants