DROSHA

This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer. [provided by RefSeq, Sep 2016]

Description

drosha ribonuclease III

Protein family

Cancer-related genes, Enzymes, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Protein evidence (Peptideatlas)

Chromosome

5:p13.3 (31400497 - 31532196)

Ensembl ID

ENSG00000113360  (ver. 99.38)

Orthologs

Mouse Drosha: ENSMUSG00000022191

UniProt

Q9NRR4

neXtProt

NX_Q9NRR4

Human splice variants
Mouse splice variants