USP18

gene product
The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15. [provided by RefSeq, Sep 2011]
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112 antibodies from 28 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
antibodies-online
40 antibodies
Novus Biologicals
7 antibodies
Abnova Corporation
8 antibodies
GeneTex
1 antibody
LifeSpan BioSciences, Inc.
11 antibodies
Invitrogen Antibodies
3 antibodies
Cell Signaling Technology, Inc
1 antibody
Biorbyt
6 antibodies
Atlas Antibodies
1 antibody
Enzo Life Sciences
2 antibodies
Acris Antibodies GmbH
2 antibodies
Boster Biological Technology
2 antibodies
Affinity Biosciences
1 antibody
NovoPro Bioscience Inc.
1 antibody
Rockland Immunochemicals, Inc.
1 antibody
ProSci
2 antibodies
OriGene
3 antibodies
Aviva Systems Biology
2 antibodies
Proteintech Group
1 antibody
RayBiotech, Inc.
1 antibody
MyBioSource
1 antibody
RabMAbs
1 antibody
Creative Biolabs
3 antibodies
Creative Diagnostics
3 antibodies
Sigma-Aldrich
2 antibodies
Abbexa
3 antibodies
Abgent
2 antibodies
EMD Millipore
1 antibody