SUN2

SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]). [supplied by OMIM, Nov 2010]

Description

Sad1 and UNC84 domain containing 2

Tissue specificity

Low tissue specificity

Subcell location

Nuclear membrane

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

22 (38734725 - 38794143)

Ensembl ID

ENSG00000100242  (ver. 103.38)

Orthologs

Mouse Sun2: ENSMUSG00000042524

UniProt

Q9UH99

neXtProt

NX_Q9UH99

Human splice variants
Mouse splice variants

Protein structure