CDH20

This gene is a type II classical cadherin from the cadherin superfamily and one of three cadherin 7-like genes located in a cluster on chromosome 18. The encoded membrane protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Since disturbance of intracellular adhesion is a prerequisite for invasion and metastasis of tumor cells, cadherins are considered prime candidates for tumor suppressor genes. [provided by RefSeq, Jul 2008]

Description

Cadherin 20

Tissue specificity

Group enriched (brain, retina, tongue)

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

18:q21.33 (61333430 - 61555779)

Ensembl ID

ENSG00000101542  (ver. 103.38)

Orthologs

Mouse Cdh20: ENSMUSG00000050840

UniProt

Q9HBT6

neXtProt

NX_Q9HBT6

Human splice variants
Mouse splice variants